Design and Synthesis Ligands Tetradents Substituted with Halogenes in α- Position and Conjugation with Riboflavin (Bioconjugates) Conjugate ligands Type TPA’s with Flavonoids as un Electron Mediator
In this article, we describe the process of binding riboflavin to a simple tetradents ligand substituted in α- position from TPAs types, by reacting bromotetraacetate riboflavin with α- substituted TPA with one of the pyridine rings by nitrile group and the two other pyridine rings by halogen atoms. This type of ligands showed very important properties for the activation and transfer of oxygen to a substrate in presence of iron salt. After the tetradents were obtained, the nitrile group was reduced to an amine group where it reacts with Boc group to protect one of the amine hydrogen and then bound to the bromotetraacetate through the amine group under special reactive conditions, to form the α-8-TPAs N- Ac4riboflavin ligands. This compound can be described as a molecular tweezers in which the flavin moiety acts as a potential electron mediator.