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Volume 1, Issue 4 (July 2022)

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Recent Developments of Stetter Reaction: A Brief Review
Jawad Kadhum Shneine
 Department of Chemistry, College of Science, Al-Nahrain University, Baghdad - Iraq
 jawad.kadem@nahrainuniv.edu.iq
 Corresponding Author
Shayma Muhsen Ahmad
 Department of Chemistry, College of Science, Al-Nahrain University, Baghdad - Iraq
Dhea Sh. Zagheer
 Department of Chemistry, College of Science, Al-Nahrain University, Baghdad - Iraq
ISSN(e): 2790-296X
ISSN(p): 2957-5826
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Prof. Dr. Emad Al-Mulla
 
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In this short review definition, mechanism, and recent developments of the Stetter reaction, in the period last ten years from 2011 to 2021 are presented. This reaction comprises N-heterocyclic carbene (NHC)-catalyzed umpolung of aldehydes followed by their capturing with activated carbon-carbon double bonds (Michael acceptors). This work includes also progresses in the inter-molecular and intra-molecular versions and enantioselective transformations. Underscoring the recent advances in the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products have been also introduced.

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Keywords: Stetter reaction, Benzoin reaction, NHC-catalysts, Asymmetric synthesis, Umpolung

How to Cite:
Shneine, J. K., Ahmad, S. M., & Zagheer, D. S. (2022). Recent Developments of Stetter Reaction: A Brief Review. Biomedicine and Chemical Sciences, 1(4), 234–240. https://doi.org/10.48112/bcs.v1i4.246 
 
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