Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity

DOI: 10.48112/bcs.v1i2.109

DiID: pub.1147451610

Vol. 1 No. 2 (2022)

Ahmed A. Majed

Education Directorate of Thi-Qar, Ministry of Education, Thi-Qar –Iraq

eduppg.ahmed.majed@uobasrah.edu.iq

0000-0003-0324-9875

Corresponding Author

Dawood S Abid

Department of Chemistry, College of education, University of Basrah, Basrah - Iraq

Abstract

The study focused on the preparation of oxadiazole derivatives containing thiazolidine. Thiazolidine firstly was prepared from the reaction of benzaldehyde with L-cysteine with a good yield and then it was reacted with acetic anhydride to prepare acetyl thiazolidine, then with ethanol in the presence of H₂SO₄, then steps were taken to prepare a thiazolidine hydrazide (A₃), which was reacted with aromatic carboxylic acid in presence POCl₃ or carbon disulphide and base KOH to obtain oxadiazole derivatives A_4-8. These compounds characterized using FT-IR, NMR and Mass (EI) were diagnosed and the synthesized compound were validated. The activity of oxadiazole derivatives were studied against breast cancer cells, the two compound A₈, A₄ showed good activity against the cells as for the compounds A₅, A₆, A₇ it was showed little activity against these cells and the value IC₅₀ was calculated.

How to Cite:

Majed, A. A., & Abid, D. S. (2022). Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity. Biomedicine and Chemical Sciences, 1(2), 83–87. https://doi.org/10.48112/bcs.v1i2.109

Publisher’s Note:

International Research and Publishing Academy (iRAPA) stands neutral with regard to jurisdictional claims in the published maps and institutional affiliations.

Copyright:

This is an Open Access article published under the Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/)

Creative Commons Attribution (CC BY): lets others distribute and copy the article, to create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, even for commercial purposes, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, and do not modify the article in such a way as to damage the author's honour or reputation.